State Route 22 (SR 22) is a 221.1-mile-long (355.8 km) state highway that runs southwest-to-northeast in an eastern arc through portions of Muscogee, Talbot, Taylor, Upson, Crawford, Bibb, Jones, Baldwin, Hancock, Taliaferro, Oglethorpe, and Madison counties in the western and west-central parts of the U.S. state of Georgia.