State Route 49 (SR 49) is a 122.8-mile-long (197.6 km) state highway that runs southwest-to-northeast through portions of Terrell, Sumter, Macon, Peach, Houston, Bibb, Jones, and Baldwin counties, mainly in the central part of the U.S. state of Georgia. The route connects SR 45 north of Dawson to SR 22/SR 24/SR 112 in Milledgeville.