"Ghetto Cowboy" is the lead single from the Mo Thugs album, Chapter II: Family Reunion. The song is produced by Romeo Antonio and performed by Krayzie Bone and Layzie Bone, both of Bone Thugs-n-Harmony, along with new members of the Mo Thugs collective, Thug Queen and Powder P and a chorus by Layzie Bone's wife Felecia.The harmonica instrumental was performed by Jimmy Zavala (aka "Jimmy Z"), who also had a popular single of his own called "Funky Flute" with Dr.