Gillon Block is an historic commercial building at 189 Main Street in Milford, Massachusetts. The three story brick building was built in 1888 by Patrick Gillon, the owner of a bottle manufacturing company. The building features elaborate brickwork on its facade, and a tower with a coppered onion dome. The building houses stores on the first floor and offices on the upper floors.The block was listed on the National Register of Historic Places in 1982.