Guthrie County is a county located in the U.S. state of Iowa. As of the 2010 census, the population was 10,954. The county seat is Guthrie Center. The county was formed on January 15, 1851 and named after Captain Edwin B. Guthrie, who had died in the Mexican–American War.Guthrie County is one of the five counties that make up the Des Moines–West Des Moines, IA Metropolitan Statistical Area.