Half & Half is an American sitcom that aired on UPN from September 23, 2002, to May 15, 2006. The show focuses on the lives of two paternal half-sisters in their twenties who were estranged throughout their childhood, and are finally developing a close relationship. The series is set in San Francisco.It was the second-most-watched show on UPN's Monday night line-up (next to Girlfriends) and fourth overall on the network.