Harry Z. Isaacs (May 30, 1904 – September 23, 1990) was a Baltimore, Maryland businessman, a philanthropist, and a major owner and breeder of Thoroughbred racehorses who operated and resided at Brookfield Farm in Glyndon, Maryland. Among his top horses, Isaacs owned Intent, whose wins included back-to-back editions of the San Juan Capistrano Handicap and who went on to sire Intentionally, Isaacs' 1959 American Champion Sprint Horse.