The Immaculate Conception with Saints (also known as The Incarnation of Jesus) is a painting by the Italian Renaissance painter Piero di Cosimo, executed between 1495 and 1505. It is housed in the Uffizi Gallery of Florence, Italy.The painting was executed for the Tebaldi Chapel in the church of the Annunziata of Florence, and was acquired by Cardinal Leopoldo de' Medici in 1670.