In Spite of Ourselves is the 13th studio album of John Prine, featuring duets with various well-known female folk and alt-country vocalists, released in 1999.The album was Prine’s first release since successfully battling throat cancer. The female duet partners include Iris DeMent, Connie Smith, Lucinda Williams, Melba Montgomery, Emmylou Harris, Trisha Yearwood, Dolores Keane, Patty Loveless, and his wife, Fiona Prine.