Interstate 376 (I-376) is a major auxiliary route of the Interstate Highway System in the U.S. state of Pennsylvania, located within the Allegheny Plateau. It runs from I-80 near Sharon south and east to a junction with the Pennsylvania Turnpike (I-76, its parent) in Monroeville, after having crossed the Turnpike at an interchange earlier in its route. The route serves Pittsburgh, Pennsylvania and its surrounding areas, and is the main access road to Pittsburgh International Airport (PIT).