Interstate 481 (I-481) is an auxiliary Interstate Highway that serves as an eastern bypass of Syracuse, New York, in the United States. It begins at its parent, I-81, in the city's southern end and travels through the eastern Syracuse suburbs of Jamesville, DeWitt, and Cicero before rejoining I-81 in the suburb of North Syracuse. After crossing I-81 in North Syracuse, I-481 continues northwest to Fulton and Oswego as New York State Route 481 (NY 481).