Interstate 64 (I-64) is an Interstate Highway in the Eastern United States. Its western terminus is at I-70, U.S. Route 40 (US 40), and US 61 in Wentzville, Missouri. Its eastern terminus is at an interchange with I-264 and I-664 at Bowers Hill in Chesapeake, Virginia.At 953.74 miles, I-64 is the second longest interstate highway not ending with a 5 or 0, after I-94.