Interstate 65 (I-65) is a major Interstate Highway in the central United States. As with most interstates that end in a five, it is a major cross-country, north-south route, connecting the Gulf of Mexico to the Great Lakes. Its southern terminus is located at an interchange with I-10 in Mobile, Alabama, and its northern terminus is at an interchange with I-90, U.S. Route 12 (US 12), and US 20 (the Dunes Highway) in Gary, Indiana, just southeast of Chicago.