Interstate 759 (I-759) is a part of the Interstate Highway System in the U.S. state of Alabama. It is a spur route that runs for 4.54 miles (7.31 km) between the cities of Attalla and Gadsden in Etowah County. It begins at an Interstate 59 (I-59) in Attalla and ends at U.S. Route 411 (US 411) in southern Gadsden adjacent to the Gadsden Mall. The route continues east as the at-grade thoroughfare State Route 759 (SR 759) until the route ends at SR 291 in Gadsden.