Isaac Bledsoe Desha (January 1, 1802 – August 13, 1828) was a 19th-century American tanner who was convicted of murdering one man in Kentucky, and confessed to murdering another in Texas. He was notable as the son of the Kentucky Governor, Joseph Desha. Shortly after his father's election as governor in 1824, Desha was accused of robbing and killing a man named Francis Baker, who was passing through Kentucky.