Isaie Melanson (October 27, 1883 – 1964 ) was a farmer and political figure of Acadian origin in New Brunswick, Canada. He represented Kent County in the Legislative Assembly of New Brunswick as a Liberal member from 1939 to 1956. His first name appears as Isaac in some sources.He was born in Sainte-Marie, New Brunswick, the son of Onésime Melanson and Geneviève Henrie. In 1911, he married Élise LeBlanc. He operated a dairy farm. Melanson served as warden for Kent County.