The Italian Wars, often referred to as the Great Italian Wars or the Great Wars of Italy and sometimes as the Habsburg–Valois Wars or the Renaissance Wars, were a series of conflicts from 1494 to 1559 that involved, at various times, most of the city-states of Italy, the Papal States, most of the major states of Western Europe (France, Spain, the Holy Roman Empire, England, and Scotland) as well as the Ottoman Empire.