James Duane (February 6, 1733 – February 1, 1797) was an American lawyer, jurist, and Revolutionary leader from New York. He served as a delegate to the Continental Congress, a New York state senator, the 44th Mayor of New York City – the first post-colonial American mayor – and a U.S. District Judge. Duane was a signer of both the Continental Association and the Articles of Confederation.