Sir James Colquhoun Irvine KBE FRS FRSE FEIS (9 May 1877 – 12 June 1952) was a Scottish organic chemist and Principal and Vice-Chancellor of the University of St Andrews from 1921 until his death. As a research chemist, Irvine worked on the application of methylation techniques to carbohydrates, and isolated the first methylated sugars, trimethyl and tetramethyl glucose.