Jessica McCullough Weis (July 8, 1901 – May 1, 1963) was a two-term Republican member of the United States House of Representatives from Rochester, New York.Weis was born in Chicago, the daughter of Charles H. McCullough Jr. and Jessie Martin McCullough. Her father was president of the Lackawanna Steel Company in Lackawanna, New York. She was educated at the Franklin School in Buffalo, at Miss Wright's School in Bryn Mawr, Pennsylvania and at Madame Rieffel's French School in New York City.