John Appleton (February 11, 1815 – August 22, 1864) was an American lawyer, politician and diplomat who served as the United States' first chargé d'affaires to Bolivia, and later as special envoy to Great Britain and Russia. Born in Beverly, Massachusetts, Appleton graduated from Bowdoin College in 1834 and attended Harvard Law School from 1835 to 1836. On leaving Harvard, he became a barrister and newspaper editor while maintaining a vigorous involvement in Democratic politics.