John Benjamin Murphy, born John Murphy (December 21, 1857 in Appleton, Wisconsin – August 11, 1916 Mackinac Island, Michigan), was an American physician and abdominal surgeon noted for advocating early surgical intervention in appendicitis appendectomy, and several eponyms: Murphy’s button, Murphy drip, Murphy’s punch, Murphy’s test, and Murphy-Lane bone skid. He is best remembered for the eponymous clinical sign that is used in evaluating patients with acute cholecystitis.