The John Downing, Jr., House is a historic house in downtown Middleport, a village located on the banks of the Ohio River in the southeastern part of the U.S. state of Ohio. Built in 1859, it was the home of prominent Middleport resident John B. Downing. Known to his intimates as "Major" Downing, he worked for much of his life as a pilot for riverboats on the Mississippi River.