John P. Wolfe (born August 12, 1970) is an American chemist and a professor of chemistry at the University of Michigan. He is best known for palladium-catalyzed C-C and C-N bond formation. He was also one of the key scientists in the development of the Buchwald ligands, one of which is appropriately named “JohnPhos”. As an educator at the University of Michigan since 2002, he has greatly influenced the undergraduate education at the University and received awards for excellence in teaching.