Knockout Reilly is a 1927 American drama silent film directed by Malcolm St. Clair and written by Pierre Collings, John W. Conway, Kenneth Raisbeck and Albert Payson Terhune. The film stars Richard Dix, Mary Brian, Jack Renault, Harry Gribbon, Osgood Perkins and Lucia Backus Seger. The film was released on April 16, 1927, by Paramount Pictures.