Lead Run is a tributary of East Branch Fishing Creek in Sullivan County, Pennsylvania. It is approximately 1.5 miles (2.4 km) long and flows through Davidson Township. Its watershed has an area of 0.82 square miles (2.1 km2). The stream has a low pH and poor water quality, although that could potentially be remedied. The main rock formations in the area are the Catskill Formation, the Huntley Mountain Formation, and the Burgoon Sandstone.