Lindsay Applegate (September 18, 1808 – November 28, 1892) was a pioneer known for blazing the Applegate Trail, an alternative end of Oregon Trail in the U.S. state of Oregon. The trail was blazed with his brothers Charles and Jesse in 1846. Charles Applegate was not a member of the party that blazed the Applegate Trail from the Willamette Valley to the Humboldt River.