Lophophora diffusa, commonly known as false peyote, is a species of plant in the Cactaceae family and one of the only two species in the Lophophora genus. It is endemic to Mexico in the outskirts of Querétaro. This species contains zero to trace amounts of mescaline; pellotine is the principal alkaloid. The species name diffusa refers to the flat tubercles that are outspread without the plant having prominent ribs.