Macho Again (foaled 2005 in Florida) is a retired American thoroughbred racehorse and sire. He was sired by the 2000 American Champion Two-Year-Old Colt Macho Uno, who in turn was a son of leading sire Holy Bull. He is out of the mare Go Donna Go, who is the daughter of Wild Again.Macho Again got his start as a two-year-old under trainer Dallas Stewart at Saratoga Race Course. He ran four times, breaking his maiden with a victory at Churchill Downs.