Macho Uno (foaled April 24, 1998 in Kentucky ) is an American Thoroughbred racehorse. He was sired by the 1994 American Horse of the Year and U.S. Racing Hall of Fame inductee, Holy Bull.Trained by Joe Orseno, Macho Uno is best known for winning the 2000 Breeders' Cup Juvenile and being voted the Eclipse Award as the American Champion Two-Year-Old Colt.Retired to stud duty, Macho Uno stands at his owner's Adena Springs South in Ocala, Florida.