Macon County is a county in the U.S. state of Alabama. As of the 2010 census, the population was 21,452. Its county seat and only city is Tuskegee. Its name is in honor of Nathaniel Macon, a member of the United States Senate from North Carolina.Developed for cotton plantation agriculture in the nineteenth century, the county is considered within the Black Belt of the South. It has had a majority-black population since before the American Civil War.In the 2004 U.S.