Manduca leucospila is a moth of the Sphingidae family. It is known from Peru, Venezuela and Bolivia.The length of the forewings is about 47 mm. It is similar in appearance to several other members of the Manduca genus, but a number of differences distinguish it from Manduca dalica, to which it most closely compares, particularly in its narrower wings and general colour which is intermediate between Manduca dalica and Manduca rustica.