Provincial Road 280 (PR 280) is a road in the Canadian province of Manitoba. It runs from PR 391 northwest of Thompson to local streets in Gillam. The route is 291 kilometres (181 mi) long, which during its length, passes several large lakes and intersects with one provincial road, PR 290, just north of Gillam. The route is very scenic, passing through dense forests and rural lands. The route supplies three municipalities, Thompson, Split Lake, and Gillam.