Maria Enriquez de Luna (1474 – 1539) was the wife of Juan (Giovanni) Borgia, second Duke of Gandia. She was a niece of King Ferdinand II of Aragon and Queen Isabella of Castile, and therefore of the House of Trastamara. She married Juan somewhere between 1493-1494, and together, they had three children: twins Juan de Borja y Enriquez (known as Juan Borgia), who became the 3rd Duke of Gandía, and Francisca de Jesus Borja, who became a nun at a convent in Valladolid.