Marshmallow creme is an American food item. It is a very sweet, spreadable, marshmallow-like confection. Marshmallow creme and peanut butter are used to create a fluffernutter sandwich. In addition, marshmallow creme and Nutella can be spread on graham crackers to emulate s'mores.One popular brand of marshmallow creme, sold principally in the Northeastern United States, is Marshmallow Fluff, manufactured by Durkee-Mower, Inc.