Mary of Lusignan (French: Marie de Lusignan; before March 1215 – 5 July 1251 or 1253), was the wife of Count Walter IV of Brienne and Countess of Brienne from the time of her marriage in 1233 to her husband's death while on Crusade in 1244. Mary's parents were King Hugh I of Cyprus and Alice of Champagne, making her a maternal granddaughter of Queen Isabella I of Jerusalem. Her two surviving sons were John, Count of Brienne, and Hugh of Brienne.