Maryland Route 452 (MD 452) is a state highway in the U.S. state of Maryland. Known as Friendship Road, the state highway runs 1.64 miles (2.64 km) from U.S. Route 50 (US 50) near Berlin north to MD 575 in Friendship in northern Worcester County. MD 452 was built as a cut-off between US 213 (now US 50) and US 113 (now MD 575) in the early 1930s.