Mayo High School for Math, Science, and Technology is a magnet high school located in Darlington, South Carolina. The school educates about 340 students in grades 9 to 12 in the Darlington County School District.Mayo High School was built around 1950 as an African-American school. At the order of a judge to become desegregated, Mayo was renovated and became a magnet school.Mayo High School earned a silver medal in the U.S. News/School Matters Best High Schools rankings.