The Mendocino County wine is an appellation that designates wine made from grapes grown mostly in Mendocino County, California. The region is part of the larger North Coast AVA and one of California's largest and most climatically diverse wine growing regions. Mendocino County is one of the northernmost commercial wine grape regions in the state with two distinct climate zones separated by the Mendocino Range. Ten American Viticultural Areas have been designated within Mendocino County.