Minnesota State Highway 16 (MN 16) is a two-lane highway in southeast Minnesota, which runs from its interchange with Interstate Highway 90 in Dexter and continues east to its eastern terminus at the Wisconsin state line concurrent with U.S. Highways 14 and 61 outside La Crescent just west of La Crosse, Wisconsin.The route was designated as a National Scenic Byway in 2003 as the Historic Bluff Country Scenic Byway. The roadway follows the route of old U.S.