The Mississippi County Jail is a historic county jail building at 300 South Poplar Street in Osceola, Arkansas. It is a three story brick structure, six bays wide, with entrances at the outer two bays, which project slightly and are set off from the central portion by brick pilasters and a decorative parapet at the roof line. The county built the jail in 1926; it is presently vacant.The building was listed on the National Register of Historic Places in 1987.