Mistissini (Cree: ᒥᔅᑎᓯᓃ/Mistisinî meaning Big Rock) is a Cree town located in the south-east corner of the largest natural lake in Quebec, Lake Mistassini (120 km long by 30 km wide). The town is inside the boundaries of the Baie-James Municipality, and is the largest Cree community with a population of 3,427 people in 2011.