Monteprandone is a comune (municipality) in the Province of Ascoli Piceno in the Italian region Marche, located about 80 kilometres (50 mi) southeast of Ancona and about 20 kilometres (12 mi) northeast of Ascoli Piceno. As of 31 December 2005, it had a population of 10,856 and an area of 26.4 square kilometres (10.2 sq mi).