The Mosopelea, or Ofo, were a Native American Siouan-speaking tribe who historically inhabited the upper Ohio River. In reaction to Iroquois Confederacy invasions to take control of hunting grounds in the late 17th-century, they moved south to the lower Mississippi River. They finally settled in central Louisiana, where they assimilated with the Siouan-speaking Biloxi and the Tunica people. They are generally classified with the speakers of the Siouan Ofo language.