Muhammad Ayub Khuhro (14 August 1901 - 1980) was a politician from Sindh, Pakistan, who became its first Chief Minister after independence of Pakistan and subsequently serving two additional terms in the 1950s. He later became the Defence Minister in the government of PM Feroz Khan Noon, before the imposition of martial law by General Ayub Khan.Khuhro was born into a landed family at Larkana in Sind province of what was then British India in 1901.