Nebraska Highway 66 is a highway in central and eastern Nebraska. It is a discontinuous highway with four segments heading in a west-to-east direction. The first segment begins at Nebraska Highway 14 south of Central City and ends at U.S. Highway 81 south of Stromsburg. The second segment begins at Nebraska Highway 15 west of Dwight and ends at Nebraska Highway 79 in Valparaiso. The third segment begins at U.S. Highway 77 south of Wahoo and ends at Main Street in Louisville.