Nefise Hatun, Nefise Sultan, Nefise Melek Hatun, or Nefise Melek Sultan Hatun (c. 1363 - c. 1400) was an Ottoman princess, the daughter of Sultan Murad I of the Ottoman Empire. She was married to Prince Alaeddin Ali of Karaman, who was a rival of the rising Ottoman Empire and became the mother of the next Karamanid ruler, Mehmed II of Karaman, who was married to Princess Incu Hatun, the daughter of Ottoman Sultan Mehmed I. Her marriage served an alliance between the Ottomans and the Karamanids.