New York State Route 406 (NY 406) is a state highway in Schenectady County, New York, in the United States. The western terminus of the route is at an intersection with U.S. Route 20 (US 20) in the town of Princetown. Its eastern terminus is at a junction with NY 158 in the town of Rotterdam. NY 406 is a two-lane highway and known as Giffords Church Road along its entire length. It was assigned to its current alignment in the mid-1930s.