New York State Route 5S (NY 5S) is an east–west state highway located in the Mohawk Valley of New York in the United States. It extends for 73.03 miles (117.53 km) from an interchange with NY 5, NY 5A, NY 8, and NY 12 in Utica to a smaller interchange with NY 890 in Rotterdam. The route runs along the south side of the Mohawk River for its entire length and parallels NY 5, which runs along the north side of the Mohawk River (hence the "S" in the route number of NY 5S).