Nicolae Constantin Paulescu (Romanian pronunciation: [nikoˈla.e pa.uˈlesku]; 30 October 1869 (O.S.) – 17 July 1931) was a Romanian physiologist, professor of medicine, and politician, the discoverer of pancreine (later called insulin). The "pancreine" was an extract of bovine pancreas in salted water, after which some impurites were removed with hydrochloric acid and sodium hydroxide.Paulescu was also, with A. C.